反应详情

A solution of 100 mg of 1d in 1 ml of dioxane was mixed with a solution of 40 mg of KOH in 400 μl of water and stirred for 16 hr at RT. The mixture was diluted with 5 ml of water and acidified to pH3 with 0.5 N HCl. The product was extracted with ethyl acetate and the extracts were washed once with sat. NaCl, dried and concentrated, to provide 65 mg of essentially pure 1e as colorless oil; MS-ESI: [M+1] 280.16; NMR (CDCl3) δ 1.54 (s, 9, tertC4H9), 2.80 (m, 2, CH2), 4.10 (bm, 2, CH2), 6.94, 7.13, 7.20 (3×m, 3, thiophene-H).

1. extractionThe product was extracted with ethyl acetate
2. washthe extracts were washed once with sat. NaCl
3. customdried
4. concentrationconcentrated