反应详情

A solution of 400 mg of 10h in 6 ml of dioxane was mixed with a solution of 180 mg of KOH in 1.5 ml of water and stirred for 2 hr at RT. The reaction mixture was diluted with 20 ml of water and acidified to pH3 by addition of 0.5N HCl. The product was extracted into ethyl acetate. The combined organic layers were once washed with water, dried and concentrated, to provide 320 mg of 10i as colorless oil:

1. extractionThe product was extracted into ethyl acetate
2. washThe combined organic layers were once washed with water
3. customdried
4. concentrationconcentrated