反应详情

温度

50 °C

A solution of 500 mg of 11g in 6 ml of dioxane was mixed with a solution of 300 mg of KOH in 3 ml of water and heated to 50° C. for 2 h. The reaction mixture was cooled and diluted with water and then acidified to pH3 by addition of 0.5N HCl. The product was extracted with ethyl acetate and the organic extract was washed once with water, dried and concentrated, to provide 480 mg of 11h as colorless amorphous material;

1. temperatureThe reaction mixture was cooled
2. extractionThe product was extracted with ethyl acetate
3. extractionthe organic extract
4. washwas washed once with water
5. customdried
6. concentrationconcentrated