Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 58124913 | HCID 58124913 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58124844 | HCID 58124844 | 101.7% |
Reaction Steps
A solution of 310 mg of 16i in 9 ml of dioxane was mixed with a solution of 200 mg of KOH in 3 ml of water and was stirred at 50° C. for 1 hr. The mixture was diluted with water and acidified to pH3 with 0.5N HCl and the product was extracted into ethyl acetate. The organic extract was washed twice with water, dried and concentrated, to give 290 mg of 16j.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08431564B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-2f1e3bafb63d4d748ce3e8abca4b6963 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
