Hydrochloric Acid → HCID 58124844, compound

HRID 1971718Notes

Reaction equation

HRID 1971718 reaction equation
[C:1]([N:5]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]#[C:19][C:20]1[S:24][CH:23]=[N:22][CH:21]=1)[C:6](=[O:12])[C:7]([O:9]CC)=[O:8])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].Cl>O1CCOCC1.O>[C:1]([N:5]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]#[C:19][C:20]1[S:24][CH:23]=[N:22][CH:21]=1)[C:6](=[O:12])[C:7]([OH:9])=[O:8])([CH3:4])([CH3:2])[CH3:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58124913HCID 58124913, compound

Product 1

HCID 58124844HCID 58124844, compoundYield 101.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 310 mg of 16i in 9 ml of dioxane was mixed with a solution of 200 mg of KOH in 3 ml of water and was stirred at 50° C. for 1 hr. The mixture was diluted with water and acidified to pH3 with 0.5N HCl and the product was extracted into ethyl acetate. The organic extract was washed twice with water, dried and concentrated, to give 290 mg of 16j.

Workup

  1. extractionthe product was extracted into ethyl acetate
  2. extractionThe organic extract
  3. washwas washed twice with water
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-2f1e3bafb63d4d748ce3e8abca4b6963
Source dataset
uspto-grants-2013_04
Patent number
US08431564B2

Reaction notes

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