反应详情

A solution of 3.5 g of 17b in 30 ml of tert-butyl amine was stirred at ambient temperature for 24 hrs. The reaction mixture was concentrated and the residues were partitioned between ethyl acetate and 5% NaHCO3. The organic layer was dried and concentrated, to provide 3.0 g of 17c as a colorles oil, which was used without further purification in next step.

1. concentrationThe reaction mixture was concentrated
2. customthe residues were partitioned between ethyl acetate and 5% NaHCO3
3. customThe organic layer was dried
4. concentrationconcentrated