Hydrochloric Acid → 2-(Tert-butyl(hex-5-ynyl)amino)-2-oxoacetic acid

Participants

Reaction Conditions

Reaction Steps

A solution of 0.7 g of 17d in 8 ml of dioxane was mixed with a solution of 0.3 g of KOH in 3 ml of water. The mixture was stirred for 2 h at 50° C. and then diluted with 30 ml of water and acidified to pH3 with 0.5 N HCl. The product was extracted with ethyl acetate. The extract was washed with water, dried and concentrated, to give 0.50 g of 19a as a colorless oil. NMR (CDCl3) δ 1.53 (s and m, 11, tertC4H9 and CH2), 1.78 (m, 2, CH2), 1.97 (t, 1, acetylene), 2.20 (m, 2, CH2), 3.56 (m, 2, CH2).

Provenance & Evidence