反应详情

温度

50 °C

A solution of 0.7 g of 17d in 8 ml of dioxane was mixed with a solution of 0.3 g of KOH in 3 ml of water. The mixture was stirred for 2 h at 50° C. and then diluted with 30 ml of water and acidified to pH3 with 0.5 N HCl. The product was extracted with ethyl acetate. The extract was washed with water, dried and concentrated, to give 0.50 g of 19a as a colorless oil. NMR (CDCl3) δ 1.53 (s and m, 11, tertC4H9 and CH2), 1.78 (m, 2, CH2), 1.97 (t, 1, acetylene), 2.20 (m, 2, CH2), 3.56 (m, 2, CH2).

1. extractionThe product was extracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. concentrationconcentrated