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HRID1971754

反应详情

EQUATION

反应方程式

HRID 1971754 的结构方程式

REACTANTS

反应物

2
结构：O=C1CCC(=O)N1Br
HCID67184

1-Bromopyrrolidine-2,5-dione

C4H4BrNO2

结构：COc1cc2c(cc1Br)-c1cc3c(n1CC2)C(=O)N(C(C)(C)C)CCCC3
HCID58124845

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2c(cc1Br)-c1c(Br)c3c(n1CC2)C(=O)N(C(C)(C)C)CCCC3
HCID58124858

未命名化合物

收率 90.7%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 506 mg of 19d in 4 ml of DMF was treated with 210 mg of NBS. The reaction was stirred for 45 min, then diluted with water, and stirred for an additional 15 min. The white precipitate was filtered and dried, to provide 543 mg of dibromide 25a.

WORKUP

后处理

  1. stirringstirred for an additional 15 min
  2. filtrationThe white precipitate was filtered
  3. customdried