反应详情

To a solution of 250 mg 27a in 7 mL dimethylformamide was added 120 mg N-bromosuccinimide. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with 2×ethyl acetate. The combined organic phases were washed with water and brine, dried and concentrated. The crude product was triturated with heptane/diisopropyl ethyl ether (1:1) to afford 230 mg of 27b as a white solid.

1. extractionthe mixture was extracted with 2×ethyl acetate
2. washThe combined organic phases were washed with water and brine
3. customdried
4. concentrationconcentrated
5. customThe crude product was triturated with heptane/diisopropyl ethyl ether (1:1)