反应详情

温度

60 °C

After adding acetonitrile (170 mL) and N-chlorosuccinimide (13.4 g, 100 mmol) to ethyl 4-amino-3-methoxybenzoate (17.8 g, 91.2 mmol) in that order, the mixture was stirred at 60° C. for 2 hours. The mixture was returned to room temperature, and the solvent in the mixture was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (mixture of n-heptane and ethyl acetate: n-heptane/ethyl acetate=8/1 then 4/1) to obtain the title compound (15.8 g, 68.8 mmol).

1. customwas returned to room temperature
2. distillationthe solvent in the mixture was distilled off under reduced pressure
3. customThe residue was purified by silica gel column chromatography (
4. additionmixture of n-heptane and ethyl acetate