Hydrogen Bromide → HCID 68561403, compound

HRID 1971793Notes

Reaction equation

HRID 1971793 reaction equation
[CH2:1]([N:5]([CH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)[C:6]1[C:7]([O:27][CH3:28])=[N:8][N:9]2[C:13]([C:14]3[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH2:22][O:23][CH3:24])=[CH:16][C:15]=3[O:25][CH3:26])=[CH:12][S:11][C:10]=12)[CH2:2][CH2:3][CH3:4].[BrH:35]>CO>[BrH:35].[CH2:1]([N:5]([CH:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1)[C:6]1[C:7]([O:27][CH3:28])=[N:8][N:9]2[C:13]([C:14]3[C:15]([O:25][CH3:26])=[CH:16][C:17]([CH2:22][O:23][CH3:24])=[CH:18][C:19]=3[O:20][CH3:21])=[CH:12][S:11][C:10]=12)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 44237814HCID 44237814, compound

Product 1

HCID 68561403HCID 68561403, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of N-butyl-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (6 mg) and methanol (1 mL) was added hydrobromic acid (8.84M, 2.0 μL), and the mixture was stirred at room temperature for 1 hour and the solvent was distilled off under reduced pressure. Methanol (1 mL) was added to the residue and the solvent was distilled off under reduced pressure. Ethyl acetate (1 mL) was added to the resultant residue and the solvent was distilled off under reduced pressure and dried to obtain the titled compound (6.0 mg).

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionMethanol (1 mL) was added to the residue
  3. distillationthe solvent was distilled off under reduced pressure
  4. additionEthyl acetate (1 mL) was added to the resultant residue
  5. distillationthe solvent was distilled off under reduced pressure
  6. customdried

Sources & evidence

ORD record
ord-bf03af366a8645cda4a9f34592e2104a
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

Loading…