Ethanol → HCID 68517302, compound

HRID 1971800Notes

Reaction equation

HRID 1971800 reaction equation
[CH:1]1([CH2:4][N:5]([CH:30]2[CH2:35][CH2:34][CH2:33][O:32][CH2:31]2)[C:6]2[C:7]([O:28][CH3:29])=[N:8][N:9]3[C:13]([C:14]4[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH2:22][O:23][CH2:24][CH3:25])=[CH:16][C:15]=4[O:26][CH3:27])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1.C(O)C.[S:39](=[O:43])(=[O:42])([OH:41])[OH:40]>C(OCC)(=O)C>[S:39]([OH:43])([OH:42])(=[O:41])=[O:40].[CH:1]1([CH2:4][N:5]([CH:30]2[CH2:35][CH2:34][CH2:33][O:32][CH2:31]2)[C:6]2[C:7]([O:28][CH3:29])=[N:8][N:9]3[C:13]([C:14]4[C:15]([O:26][CH3:27])=[CH:16][C:17]([CH2:22][O:23][CH2:24][CH3:25])=[CH:18][C:19]=4[O:20][CH3:21])=[CH:12][S:11][C:10]=23)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 57912449HCID 57912449, compound

Product 1

HCID 68517302HCID 68517302, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of N-(cyclopropylmethyl)-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(tetrahydro-2H-pyran-3-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (42.0 mg), ethanol (2 mL) and ethyl acetate (1 mL) was added concentrated sulfuric acid (4.46 μL). The mixture was stirred at room temperature for 2 hours and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (45.7 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-ddb3d81eb8be4cf5b9dc4de6c4f59178
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

Loading…