Sulfuric Acid → HCID 68512858, compound

HRID 1971801Notes

Reaction equation

HRID 1971801 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([C:13]2[N:14]3[N:20]=[C:19]([O:21][CH3:22])[C:18]([N:23]([CH2:30][CH2:31][CH3:32])[CH:24]4[CH2:29][CH2:28][CH2:27][O:26][CH2:25]4)=[C:15]3[S:16][CH:17]=2)=[C:7]([O:33][CH3:34])[CH:6]=1)[CH3:2].[S:35](=[O:39])(=[O:38])([OH:37])[OH:36]>C(O)C>[S:35]([OH:39])([OH:38])(=[O:37])=[O:36].[CH2:1]([O:3][CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([C:13]2[N:14]3[N:20]=[C:19]([O:21][CH3:22])[C:18]([N:23]([CH2:30][CH2:31][CH3:32])[CH:24]4[CH2:29][CH2:28][CH2:27][O:26][CH2:25]4)=[C:15]3[S:16][CH:17]=2)=[C:7]([O:33][CH3:34])[CH:6]=1)[CH3:2]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 44482380HCID 44482380, compound

Product 1

HCID 68512858HCID 68512858, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-3-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (8.1 mg) and ethanol (2 mL) was added concentrated sulfuric acid (0.88 μL). The mixture was stirred at room temperature for 2 hours and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (9.8 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-61da6754c04649fda76c80553f638278
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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