4-Fluoro-2-(morpholine-4-sulfonyl)-phenol → tert-Butyl-4-(2-(6-(benzyloxy)-7-((1-(4-fluorophenyl)-3-oxopropan-2-ylthio)carbonyl)-5-oxoimidazo[1,2-a]pyrimidin-1(5H)-yl)acetyl)piperazine-1-carboxylate

HRID 1971841Notes

Reaction equation

HRID 1971841 reaction equation
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[CH:17][N:18]([CH2:19][C:20]([N:22]3[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]3)=[O:21])[C:12]2=[N:11][C:10]=1[C:35](=[O:37])[SH:36])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:38][C:39]1[CH:44]=[CH:43][C:42](O)=[C:41](S(N2CCOCC2)(=O)=O)[CH:40]=1>>[C:31]([O:30][C:28]([N:25]1[CH2:26][CH2:27][N:22]([C:20](=[O:21])[CH2:19][N:18]2[C:12]3=[N:11][C:10]([C:35]([S:36][CH:2]([CH:1]=[O:8])[CH2:3][C:42]4[CH:41]=[CH:40][C:39]([F:38])=[CH:44][CH:43]=4)=[O:37])=[C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:14](=[O:15])[N:13]3[CH:16]=[CH:17]2)[CH2:23][CH2:24]1)=[O:29])([CH3:32])([CH3:33])[CH3:34]

Participants

3

Reactant 2

HCID 581269904-Fluoro-2-(morpholine-4-sulfonyl)-phenolHCID 1233373876-(Benzyloxy)-1-(2-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-oxoethyl)-5-oxo-1,5-dihydroimidazo[1,2-a]pyrimidine-7-carbothioic S-acid

Product 1

HCID 87206166tert-Butyl-4-(2-(6-(benzyloxy)-7-((1-(4-fluorophenyl)-3-oxopropan-2-ylthio)carbonyl)-5-oxoimidazo[1,2-a]pyrimidin-1(5H)-yl)acetyl)piperazine-1-carboxylate

Procedure

Adapted from the procedure of example 39 using the product of example 109 and the product of example 84

Sources & evidence

ORD record
ord-5be1c17d35054ea7b57df5cce9ea9cf5
Source dataset
uspto-grants-2013_04
Patent number
US08431581B2

Reaction notes

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