Benzenemethanamine, 3,4-dichloro- → HCID 58126881, compound

HRID 1971855Notes

Reaction equation

HRID 1971855 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]2[N:15]([CH2:16][C:17]([N:19]3[CH2:24][CH:23]([CH3:25])[CH2:22][CH:21]([CH3:26])[CH2:20]3)=[O:18])[CH:14]=[C:13]([CH2:27][S:28][CH3:29])[N:8]2[C:9](=[O:12])[C:10]=1[OH:11])=O.[Cl:30][C:31]1[CH:32]=[C:33]([CH:36]=[CH:37][C:38]=1[Cl:39])[CH2:34][NH2:35]>>[Cl:30][C:31]1[CH:32]=[C:33]([CH:36]=[CH:37][C:38]=1[Cl:39])[CH2:34][NH:35][C:3]([C:5]1[N:6]=[C:7]2[N:15]([CH2:16][C:17]([N:19]3[CH2:20][CH:21]([CH3:26])[CH2:22][CH:23]([CH3:25])[CH2:24]3)=[O:18])[CH:14]=[C:13]([CH2:27][S:28][CH3:29])[N:8]2[C:9](=[O:12])[C:10]=1[OH:11])=[O:2]

Participants

3

Reactant 2

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 58126903HCID 58126903, compound

Product 1

HCID 58126881HCID 58126881, compoundYield 76.4%

Procedure

Following the same procedure for Example 49 but using 1-[2-(3,5-dimethyl-piperidin-1-yl)-2-oxo-ethyl]-6-hydroxy-3-methylsulfanylmethyl-5-oxo-1,5-dihydro-imidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester from step 2 and 3,4-dichlorobenzylamine, the title product was obtained in 76.4% yield as a yellowish amorphous solid.

Sources & evidence

ORD record
ord-424c3081c4d84aafb04fe9e664507e1c
Source dataset
uspto-grants-2013_04
Patent number
US08431581B2

Reaction notes

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