Hydrochloric Acid → HCID 67372091, compound

HRID 1971997Notes

Reaction equation

HRID 1971997 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[N:16]=[N:17][C:18]([CH:34]3[CH2:37][CH2:36][CH2:35]3)=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:23][CH:22]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:38]>C(Cl)Cl.O1CCOCC1>[ClH:38].[ClH:38].[CH:34]1([C:18]2[N:17]=[N:16][C:15]([O:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:20][C:19]=2[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)=[CH:25][CH:26]=2)[CH2:37][CH2:36][CH2:35]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67373305HCID 67373305, compound

Product 1

HCID 67372091HCID 67372091, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[6-cyclobutyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (0.35 mmol, 0.18 g) in DCM (1.0 mL) was added 4 N HCl in dioxane (1.0 mL) and the reaction was stirred for 30 min. The solvents were removed under reduced pressure and the residue was triturated with anhydrous ethyl ether and filtered to give 3-cyclobutyl-4-(4-cyclohexyloxy-phenyl)-6-(piperidin-4-yloxy)-pyridazine dihydrochloride (0.14 g).

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was triturated with anhydrous ethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-72f343ceda024dc39ae6a4f39bc93850
Source dataset
uspto-grants-2013_04
Patent number
US08431575B2

Reaction notes

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