反应详情

温度

120 °C

A mixture of 3-(3-bromo-4-cyclohexyloxy-phenyl)-2-hydroxy-4-oxo-octanoic acid ethyl ester (4.39 mmol, 2.0 g) and hydrazine hydrate (2.0 mL) in acetic acid (10 mL) was kept stirring at 120° C. for 3 h. The reaction mixture was concentrated under reduced pressure and to the residue was added water, extracted with ethyl acetate dried and concentrated under reduced pressure, dried to provide 5-(3-bromo-4-cyclohexyloxy-phenyl)-6-butyl-pyridazin-3-ol (1.7 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure and to the residue
2. additionwas added water
3. extractionextracted with ethyl acetate
4. customdried
5. concentrationconcentrated under reduced pressure
6. customdried