HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86640991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86640990 | HCID 86640990 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86640991 | HCID 86640991 | 75% |
Reaction Steps
tert-Butyl 4-(2-(4-(2-methylpyridin-3-yloxy)-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate (0.14 g, 0.22 mmol was dissolved in dichloromethane (2 mL) and charged with HCl (2N in diethyl ether, 3 mL). After stirring at ambient temperature for 2 hours, the solution was concentrated and dried under high vacuum to give the title compound (0.10 g, 75% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431713B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-7d20fe29f395492996611b5d73ad6ae8 |
| Source note | uspto-grants-2013_04 |