Hydrochloric Acid → HCID 86640991, compound

HRID 1972176Notes

Reaction equation

HRID 1972176 reaction equation
[CH3:1][C:2]1[C:7]([O:8][C:9]2[C:14]([S:15][C:16]3[CH:21]=[CH:20][N:19]=[C:18]4[CH:22]=[CH:23][S:24][C:17]=34)=[CH:13][N:12]=[C:11]([NH:25][C:26]3[S:27][CH:28]=[C:29]([CH:31]4[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]4)[N:30]=3)[CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:44]>ClCCl>[ClH:44].[ClH:44].[CH3:1][C:2]1[C:7]([O:8][C:9]2[C:14]([S:15][C:16]3[CH:21]=[CH:20][N:19]=[C:18]4[CH:22]=[CH:23][S:24][C:17]=34)=[CH:13][N:12]=[C:11]([NH:25][C:26]3[S:27][CH:28]=[C:29]([CH:31]4[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]4)[N:30]=3)[CH:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86640990HCID 86640990, compound

Product 1

HCID 86640991HCID 86640991, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(2-(4-(2-methylpyridin-3-yloxy)-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate (0.14 g, 0.22 mmol was dissolved in dichloromethane (2 mL) and charged with HCl (2N in diethyl ether, 3 mL). After stirring at ambient temperature for 2 hours, the solution was concentrated and dried under high vacuum to give the title compound (0.10 g, 75% yield) as a white solid.

Workup

  1. concentrationthe solution was concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-7d20fe29f395492996611b5d73ad6ae8
Source dataset
uspto-grants-2013_04
Patent number
US08431713B2

Reaction notes

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