Hydrochloric Acid → HCID 86653819, compound

HRID 1972183Notes

Reaction equation

HRID 1972183 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][C@H:5]([N:10](OC(C)(C)C)C(C(OC(C)(C)C)=O)=O)[C:6]([O:8]C)=[O:7].[ClH:25]>>[ClH:25].[NH2:10][C@@H:5]([CH2:4][CH2:3][CH2:2][Br:1])[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86653821HCID 86653821, compound

Product 1

HCID 86653819HCID 86653819, compoundYield 98%

Procedure

Finally, 2.33 g of methyl(S)-5-bromo-2-{(tert-butoxy)-N-[(tert-butyl)oxy-carbonyl]carbonylamino}-1-pentanoate was stirred in 50 ml of 4N HCl at 60° C. for 24 hours and then concentrated to obtain 1.29 g (98%) of (S)-2-amino-5-bromo-pentanoic acid hydrochloride.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-2ab860c0d2ac49e59669d2454d74a36c
Source dataset
uspto-grants-2013_04
Patent number
US08431738B2

Reaction notes

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