Sodium Hydroxide → HCID 86653824, compound

HRID 1972185Notes

Reaction equation

HRID 1972185 reaction equation
C([NH:4][CH:5]([CH2:9][CH2:10][CH:11]([Br:15])[CH2:12][CH2:13][CH3:14])[C:6]([OH:8])=[O:7])(=O)C.[OH-].[Na+]>O>[NH2:4][C@@H:5]([CH2:9][CH2:10][CH:11]([Br:15])[CH2:12][CH2:13][CH3:14])[C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86653822HCID 86653822, compound

Product 1

HCID 86653824HCID 86653824, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
37 °C

Procedure

To 2-(N-acetylamino)-5-bromooctanoic acid (3.0 g), 20 ml of water was added and 1N NaOH was added to adjust the pH to 8. After warming to 37° C., 400 mg of Aspergillus genus aminoacylaze was added, followed by stirring for 24 hours. After cooling in an ice bath, the obtained precipitate was collected by filtration. The product obtained by filtration was washed with water and ethanol until color disappeared. After drying, 658 mg (52%) of (S)-2-amino-5-bromooctanoic acid was obtained as a white crystal.

Workup

  1. addition400 mg of Aspergillus genus aminoacylaze was added
  2. temperatureAfter cooling in an ice bath
  3. filtrationthe obtained precipitate was collected by filtration
  4. customThe product obtained by filtration
  5. washwas washed with water and ethanol until color
  6. customAfter drying

Sources & evidence

ORD record
ord-f1896fb9cbec4146a304045d2c80f507
Source dataset
uspto-grants-2013_04
Patent number
US08431738B2

Reaction notes

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