Sodium Hydroxide → HCID 59485623, compound

HRID 1972216Notes

Reaction equation

HRID 1972216 reaction equation
[Cl:1][C:2]1[CH:36]=[CH:35][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=4)[CH2:16][N:15]([CH2:28][C:29]([O:31]CC)=[O:30])[C:14]3=[O:34])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=4)[CH2:16][N:15]([CH2:28][C:29]([OH:31])=[O:30])[C:14]3=[O:34])=[CH:11][CH:12]=2)=[CH:35][CH:36]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 24946010HCID 24946010, compound

Product 1

HCID 59485623HCID 59485623, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)acetate (12.0 mg, 0.023 mmol) in EtOH (0.5 mL) is added 1N NaOH aqueous solution (115 μL, 0.12 mmol). The mixture is stirred at room temperature overnight before removal of the solvent. The residue is purified by preparatory LC/MS to provide the title compound; HPLC-MS calculated for C26H22ClF3N2O4 (M+H+) 491.1, found 491.1.

Workup

  1. customThe residue is purified by preparatory LC/MS

Sources & evidence

ORD record
ord-920ec623c7a843f3b1cfc264ccbdf0d5
Source dataset
uspto-grants-2013_04
Patent number
US08431607B2

Reaction notes

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