Ethanolamine → HCID 59485732, compound

HRID 1972225Notes

Reaction equation

CS(O[CH2:6][CH2:7][N:8]1[CH2:12][CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[N:10]([C:23]2[CH:28]=[CH:27][C:26]([O:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)=[CH:25][CH:24]=2)[C:9]1=[O:37])(=O)=O.[NH2:38][CH2:39][CH2:40][OH:41]>C1COCC1>[Cl:36][C:33]1[CH:32]=[CH:31][C:30]([O:29][C:26]2[CH:25]=[CH:24][C:23]([N:10]3[CH:11]([C:13]4[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:20])([F:22])[F:21])[CH:14]=4)[CH2:12][N:8]([CH2:7][CH2:6][NH:38][CH2:39][CH2:40][OH:41])[C:9]3=[O:37])=[CH:28][CH:27]=2)=[CH:35][CH:34]=1

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazolidin-1-yl)ethyl methanesulfonate (12.0 mg, 0.0216 mmol) in THF (0.3 mL) is added 2-aminoethanol (6.53 μL, 0.108 mmol). The reaction mixture is heated at 80° C. for 2 h before removal of the solvent. The residue is purified by preparatory LC/MS to provide the title compound; HPLC-MS calculated for C26H25ClF3N3O3 (M+H+) 520.2, found 520.2.

Workup

customThe residue is purified by preparatory LC/MS

Sources & evidence

ORD record: ord-25a743bc7f4345959bdb03dc9447f361
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08431607B2

Reaction notes

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