Hydrochloric Acid → HCID 86670303, compound

HRID 1972347Notes

Reaction equation

HRID 1972347 reaction equation
[CH3:1][C@@H:2]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:23])([C:19]([F:22])([F:21])[F:20])[C:15]([F:18])([F:17])[F:16])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4](C([O-])=O)[CH2:3]1.[ClH:27]>O1CCOCC1>[ClH:27].[F:18][C:15]([F:16])([F:17])[C:14]([C:11]1[CH:10]=[CH:9][C:8]([N:7]2[CH2:6][CH2:5][NH:4][CH2:3][C@@H:2]2[CH3:1])=[CH:13][CH:12]=1)([OH:23])[C:19]([F:22])([F:21])[F:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86670305HCID 86670305, compound

Product 1

HCID 86670303HCID 86670303, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 100 mL round-bottomed flask was charged with (3S)-3-methyl-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate (0.250 g, 0.565 mmol) and 10 mL of 4N HCl in dioxane. After 2 h at room temperature, the mixture was concentrated to give (S)-1,1,1,3,3,3-hexafluoro-2-(4-(2-methylpiperazin-1-yl)phenyl)-2-propanol hydrochloride as a yellow foam (0.214 g) which was used without purification.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-d7524cf5a3cf443f8d1287e32f2ef0dd
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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