Hydrochloric Acid → HCID 66582443, compound

Participants

Reaction Conditions

Reaction Steps

A 100 mL round-bottomed flask was charged with ((3S)-3-methyl-4-(5-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyrimidinyl)-1-piperazinecarboxylate (1.12 g, 2.87 mmol), 10 mL of EtOAc, and 3 mL of 4N HCl in dioxane. The mixture was heated at 80° C. for 3 h. The resulting white precipitate was collected by filtration to give 1,1,1-trifluoro-2-(2-((2S)-2-methyl-1-piperazinyl)-5-pyrimidinyl)-2-propanol dihydrochloride (1.05 g)

Provenance & Evidence