Hydrochloric Acid → HCID 66582443, compound

HRID 1972357Notes

Reaction equation

[CH3:1][C@@H:2]1[N:7]([C:8]2[N:13]=[CH:12][C:11]([C:14]([OH:20])([CH3:19])[C:15]([F:18])([F:17])[F:16])=[CH:10][N:9]=2)[CH2:6][CH2:5][N:4](C([O-])=O)[CH2:3]1.CCOC(C)=O.[ClH:30]>O1CCOCC1>[ClH:30].[ClH:30].[F:18][C:15]([F:16])([F:17])[C:14]([C:11]1[CH:10]=[N:9][C:8]([N:7]2[CH2:6][CH2:5][NH:4][CH2:3][C@@H:2]2[CH3:1])=[N:13][CH:12]=1)([OH:20])[CH3:19]

Participants

Conditions

Temperature: 80 °C

Procedure

A 100 mL round-bottomed flask was charged with ((3S)-3-methyl-4-(5-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyrimidinyl)-1-piperazinecarboxylate (1.12 g, 2.87 mmol), 10 mL of EtOAc, and 3 mL of 4N HCl in dioxane. The mixture was heated at 80° C. for 3 h. The resulting white precipitate was collected by filtration to give 1,1,1-trifluoro-2-(2-((2S)-2-methyl-1-piperazinyl)-5-pyrimidinyl)-2-propanol dihydrochloride (1.05 g)

Workup

filtrationThe resulting white precipitate was collected by filtration

Sources & evidence

ORD record: ord-20fced5590234517a5c70e270fe8dd4b
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08431563B2

Reaction notes

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