Dichloromethane → HCID 66582650, compound

HRID 1972369Notes

Reaction equation

HRID 1972369 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C(Cl)Cl.C(N(CC)CC)C.[C:24]1([S:30](Cl)(=[O:32])=[O:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([S:30]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:32])=[O:31])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 27356291-(4-Bromophenyl)piperazine

Product 1

HCID 66582650HCID 66582650, compoundYield 94.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 500 mL round-bottomed flask was charged with 1-(4-bromophenyl)piperazine (10.00 g, 41.5 mmol, Combi-Blocks, San Diego, Calif.) and 100 mL of CH2Cl2. To this was slowly added triethylamine (6.94 mL, 49.8 mmol) and benzenesulfonyl chloride (6.15 mL, 47.7 mmol). After 15 min at room temperature, the mixture was diluted with water (100 mL) and layers were separated. The organics were dried (MgSO4) and concentrated. The resulting solid was slurried with diethyl ether (200 mL) to give 1-(4-bromophenyl)-4-(phenylsulfonyl)piperazine (15.00 g) as a white solid.

Workup

  1. customwere separated
  2. dry with materialThe organics were dried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-bc7622e34a3649ce9e84a878a55aa00b
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

Loading…