Dichloromethane → HCID 66583112, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[CH2:6][CH:7]1[CH2:12][NH:11][CH2:10][CH2:9][NH:8]1.C(Cl)Cl.C(N(CC)CC)C.[S:26]1[CH:30]=[CH:29][CH:28]=[C:27]1[S:31](Cl)(=[O:33])=[O:32]>C([O-])(O)=O.[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[CH2:6][CH:7]1[NH:8][CH2:9][CH2:10][N:11]([S:31]([C:27]2[S:26][CH:30]=[CH:29][CH:28]=2)(=[O:33])=[O:32])[CH2:12]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
To a 100-mL round-bottomed flask was added 2-(3-methoxybenzyl)piperazine (128 mg, 0.62 mmol), 5 mL of CH2Cl2, triethylamine (0.129 mL, 0.93 mmol) and 2-thiophenesulfonyl chloride (0.113 mL, 0.62 mmol, Aldrich, St. Louis, Mo.). The reaction mixture was stirred at 0° C. for 1 h and then diluted with aqueous saturated NaHCO3 (5 mL) and extracted with EtOAc (2×30 mL). The organic extracts were washed with saturated NaCl (10 mL) and dried over Na2SO4. The solution was filtered and concentrated in vacuo to give the crude material as a light-yellow oil. The crude product was purified by silica gel chromatography, eluting with 5% MeOH in EtOAc to give 3-(3-methoxybenzyl)-1-(thiophen-2-ylsulfonyl)piperazine as a colorless oil (162 mg).
Workup
- extractionextracted with EtOAc (2×30 mL)
- washThe organic extracts were washed with saturated NaCl (10 mL)
- dry with materialdried over Na2SO4
- filtrationThe solution was filtered
- concentrationconcentrated in vacuo
- customto give the crude material as a light-yellow oil
- customThe crude product was purified by silica gel chromatography
- washeluting with 5% MeOH in EtOAc
Sources & evidence
- ORD record
- ord-c18cfbd9fb2542df86b5d76790f4fcad
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08431563B2
Reaction notes
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