反应详情

温度

70 °C

To a 100-mL round-bottomed flask was added ethyl glycyl-3-(6-methoxy-2-pyridinyl)alaninate (945 mg, 3.36 mmol) and N,N-diisopropylethylamine (0.58 mL, 3.36 mmol) in MeOH (20 mL). The reaction mixture was stirred at 70° C. for two days. The mixture was allowed to cool to room temperature. The solid that formed was collected by filtration, washed with MeOH, and dried to give 3-((6-methoxy-2-pyridinyl)methyl)-2,5-piperazinedione (426 mg) as a white solid.

1. temperatureto cool to room temperature
2. customThe solid that formed
3. filtrationwas collected by filtration
4. washwashed with MeOH
5. customdried