反应详情

温度

70 °C

To a 100-mL round-bottomed flask was added ethyl glycyl-3-(2-methoxy-4-pyridinyl)alaninate (1.70 g, 6.03 mmol) and N,N-diisopropylethylamine (1.05 mL, 6.03 mmol) in MeOH (20 mL). The reaction mixture was stirred at 70° C. for 18 h and allowed to cool to room temperature. The solid formed was filtered and washed with MeOH to give 3-((2-methoxy-4-pyridinyl)methyl)-2,5-piperazinedione (1.32 g) as a white solid.

1. temperatureto cool to room temperature
2. customThe solid formed
3. filtrationwas filtered
4. washwashed with MeOH