Ammonium Hydroxide → HCID 66582686, compound

HRID 1972687Notes

Reaction equation

HRID 1972687 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:12]=[N:13][C:14](Cl)=[CH:15][CH:16]=2)(=[O:10])=[O:9])=[N:6][CH:7]=1.[NH4+:18].[OH-]>CCO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:18])=[N:13][CH:12]=2)(=[O:10])=[O:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 86670439HCID 86670439, compound

Product 1

HCID 66582686HCID 66582686, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

5-Bromo-2-((6-chloro-3-pyridinyl)sulfonyl)pyridine (298 mg, 0.89 mmol), NH4OH (aqueous, 3 mL), and EtOH (3 mL) were added to a high-pressure reaction vessel. The vessel was sealed and heated at 120° C. for 2 h. After cooling to room temperature, the solvent was partially removed under vacuum. The white precipitate obtained was filtered, washed with ether, and dried under vacuum to provide 5-((5-bromo-2-pyridinyl)sulfonyl)-2-pyridinamine (280 mg) as a white solid that was used without further purification.

Workup

  1. customThe vessel was sealed
  2. temperatureAfter cooling to room temperature
  3. customthe solvent was partially removed under vacuum
  4. customThe white precipitate obtained
  5. filtrationwas filtered
  6. washwashed with ether
  7. customdried under vacuum

Sources & evidence

ORD record
ord-da35a3b76e094ca282ecd82687d2c22b
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

Loading…