HCID 59231991, compound → HCID 58529467, compound

HRID 1972731Notes

Reaction equation

HRID 1972731 reaction equation
[NH2:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.N[C:25]1C2=CC=C(C3CCN(C(OC(C)(C)C)=O)CC=3)N2N=CN=1>>[NH2:1][C:2]1[C:7]2=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15][CH2:16]3)[N:6]2[N:5]=[C:4]([CH3:25])[N:3]=1

Participants

3

Reactant 2

HCID 59231991HCID 59231991, compoundHCID 59232077HCID 59232077, compound

Product 1

HCID 58529467HCID 58529467, compound

Procedure

The title compound was prepared in the same manner described for the preparation of tert-butyl 4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate and substituting tert-butyl 4-(4-amino-2-methylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,6-dihydropyridine-1(2H)-carboxylate for tert-butyl 4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,6-dihydropyridine-1(2H)-carboxylate. 1H-NMR (CD2 Cl2): δ 6.59 (d, 1 H), 6.41 (d, 1 H), 5.53 (br s, 2 H), 4.18 (m, 2 H), 3.33 (m, 1 H), 2.89 (m, 2 H), 2.36 (s, 3 H), 2.03 (m, 2 H), 1.58 (m, 2 H), 1.45 (s, 9 H). MS: LC/MS (+esi), m/z=332 [M+H]. RT=2.39 min.

Sources & evidence

ORD record
ord-46677fb2929442038e0d801d7f6bd424
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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