HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1972846Generated: October 31, 2026
1-Methylpiperazine → 4-Methyl-1-piperazinecarbonyl chloride
https://huagongshe.com/reaction/1972846
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Methyl-1-piperazinecarbonyl chloride | HCID 3016935 | — |
Reaction Steps
To solution of methyl piperazine (166 uL, 1.50 mmol) In anhydrous dichloromethane (2 mL), diisopropyl ethyl amine (300 uL, 1.72 mmol) was added. The reaction was cooled to 0° C. under N2. Triphosgene (240 mg, 0.809 mmol) was added and the reaction was allowed to warm to rt. The chloride was used immediately without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08431695B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-f5befe15aea745639bf0cfd5f774b9bd |
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| Source note | uspto-grants-2013_04 |
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