1-Methylpiperazine → 4-Methyl-1-piperazinecarbonyl chloride

HRID 1972846Notes

Reaction equation

HRID 1972846 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(N(C(C)C)CC)(C)C.[Cl:17][C:18](Cl)([O:20]C(=O)OC(Cl)(Cl)Cl)Cl>ClCCl>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:18]([Cl:17])=[O:20])[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 531671-MethylpiperazineHCID 81531DiisopropylethylamineHCID 94429Triphosgene

Product 1

HCID 30169354-Methyl-1-piperazinecarbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To solution of methyl piperazine (166 uL, 1.50 mmol) In anhydrous dichloromethane (2 mL), diisopropyl ethyl amine (300 uL, 1.72 mmol) was added. The reaction was cooled to 0° C. under N2. Triphosgene (240 mg, 0.809 mmol) was added and the reaction was allowed to warm to rt. The chloride was used immediately without purification.

Workup

  1. temperatureto warm to rt
  2. customThe chloride was used immediately without purification

Sources & evidence

ORD record
ord-f5befe15aea745639bf0cfd5f774b9bd
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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