HCID 59231971, compound → HCID 59232026, compound

HRID 1972964Notes

Reaction equation

HRID 1972964 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([Br:24])[CH:9]=[C:10]([CH:11]3CCN(C(OC(C)(C)C)=O)C[CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.NC1C2=CC=C(CC[OH:37])N2N=CN=1>>[NH2:1][C:2]1[C:7]2=[C:8]([Br:24])[CH:9]=[C:10]([CH2:11][CH2:12][OH:37])[N:6]2[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 59231971HCID 59231971, compoundHCID 59232069HCID 59232069, compound

Product 1

HCID 59232026HCID 59232026, compound

Procedure

This compound was prepared in a manner similar to the bromination procedure described for the preparation of tert-butyl 4-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidine-1-carboxylate, using 2-(4-amino-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-ethanol as the starting material. 1H NMR (300 MHz, DMSO-d6) δ 7.83 (s, 1H), 6.64 (s, 1H), 4.75 (t, 1H), 3.65 (q, 2H), 2.96 (t, 2H); ES-MS m/z 257.3/259.2 [M+H]+, RT (min) 0.35.

Workup

  1. customThis compound was prepared in a manner similar to the bromination procedure
  2. customES-MS m/z 257.3/259.2 [M+H]+, RT (min) 0.35

Sources & evidence

ORD record
ord-78e0ff260fbf4bd19ffa1279e012b904
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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