2-chloro-N,N-dimethylacetamide → HCID 58529882, compound

HRID 1973022Notes

Reaction equation

HRID 1973022 reaction equation
[CH:1]1([CH2:5][N:6]2[CH:14]=[C:13]3[C:8]([CH:9]=[C:10]([C:15]4[CH:16]=[C:17]([CH:25]5[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]5)[N:18]5[C:23]=4[C:22]([NH2:24])=[N:21][CH:20]=[N:19]5)[CH:11]=[CH:12]3)=[N:7]2)[CH2:4][CH2:3][CH2:2]1.ClC[C:33]([N:35]([CH3:37])[CH3:36])=[O:34]>>[NH2:24][C:22]1[C:23]2=[C:15]([C:10]3[CH:11]=[CH:12][C:13]4[C:8]([CH:9]=3)=[N:7][N:6]([CH2:5][CH:1]3[CH2:2][CH2:3][CH2:4]3)[CH:14]=4)[CH:16]=[C:17]([CH:25]3[CH2:30][CH2:29][N:28]([C:33]([N:35]([CH3:37])[CH3:36])=[O:34])[CH2:27][CH2:26]3)[N:18]2[N:19]=[CH:20][N:21]=1

Participants

3

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 58529777HCID 58529777, compound

Product 1

HCID 58529882HCID 58529882, compoundYield 85%

Procedure

In a manner similar to the procedure described for Example 369 and using 5-[2-(cyclobutylmethyl)-2H-indazol-6-yl]-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine and substituting dimethylcarbamyl chloride for 2-chloro-N,N-dimethylacetamide as starting materials, 60 mg, (85%) of the desired product was isolated. LC-MS [M+H]+=473.3, RT=2.55 min.

Sources & evidence

ORD record
ord-7539027749764b6f84e22c22e927cc89
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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