Phosphorus oxychloride → HCID 22763500, compound

HRID 1973041Notes

Reaction equation

HRID 1973041 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]([C:15]([NH2:17])=O)=[C:8]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:4]=2[CH:3]=1.P(Cl)(Cl)(Cl)=O>>[Br:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]([C:15]#[N:17])=[C:8]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 22763480HCID 22763480, compound

Product 1

HCID 22763500HCID 22763500, compound

Procedure

Reflux 2.1 g. 5-bromo-3-phenylbenzo [b ]thiophene-2-carboxamide (0.0063 mole) together with 10 ml. of phosphorus oxychloride for 11/2 hours and then carefully pour onto ice water. Filter off the white precipitate. Dry. Recrystallize the title compound from methanol; m.p. 145°-146°.

Workup

  1. temperatureReflux 2.1 g
  2. filtrationFilter off the white precipitate
  3. customDry
  4. customRecrystallize the title compound from methanol

Sources & evidence

ORD record
ord-b524d52c5d2e4b14aeb2b10c82cfeb87
Source dataset
uspto-grants-1976_12
Patent number
US03996159

Reaction notes

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