Methanol → HCID 53946804, compound

HRID 1973052Notes

Reaction equation

HRID 1973052 reaction equation
[CH2:1]=[CH:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5](CCl)[CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:17]O.[CH3:19][CH:20]1[CH2:22][NH:21]1>O>[CH:2]([C:3]1[CH:4]=[CH:5][C:6]([CH2:17][N:21]2[CH2:22][CH:20]2[CH3:19])=[CH:7][CH:8]=1)=[CH2:1]

Participants

6

Reactant 4

HCID 887MethanolHCID 63772-MethylaziridineHCID 11430Potassium CarbonateHCID 170249ar-Vinylbenzyl chloride

Product 1

HCID 53946804HCID 53946804, compoundYield 87.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared in a manner analogous to Example 1. The components were ar-vinyl-benzyl chloride (approximately 95% para isomer, 0.249 mol.), potassium carbonate (50.0 g.), anhydrous methanol (1000 ml.) and 2-methylaziridine (70 ml.; 0.974 mol.). Distillation of the crude product (a brown oil) gave 7.6 g. of a water-white liquid boiling at about 85°C. under 0.2-0.3 mm. of Hg pressure. VPC analysis showed this fraction to contain 87.1% of the desired product. The product was obtained from the VPC fractionation and its structure confirmed by IR, NMR and elemental analysis.

Workup

  1. customThe title compound was prepared in a manner analogous to Example 1
  2. distillationDistillation of the crude product (a brown oil)
  3. customgave 7.6 g
  4. customThe product was obtained from the VPC fractionation and its structure

Sources & evidence

ORD record
ord-bf3d56f492ae4dafb8edaaa3b2f0747d
Source dataset
uspto-grants-1976_12
Patent number
US03996204

Reaction notes

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