HCID 20390097, compound → HCID 70622682, compound

HRID 1973085Notes

Reaction equation

HRID 1973085 reaction equation
[CH3:1][CH:2]1[CH2:11][C:10]2[N:9]([CH:12]([CH3:14])[CH3:13])[C:8](=[O:15])[N:7]=[C:6]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:5]=2[CH2:4][CH2:3]1>[Pd].C1(C)C(C)=CC=CC=1>[CH3:1][C:2]1[CH:11]=[C:10]2[CH:5]([CH:6]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:7][C:8](=[O:15])[N:9]2[CH:12]([CH3:14])[CH3:13])[CH2:4][CH:3]=1

Participants

4

Reactant 1

HCID 20390097HCID 20390097, compound

Product 1

HCID 70622682HCID 70622682, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 7237O-XyleneSolvent

Procedure

To 14 g. of 7-methyl-1-isopropyl-4-phenyl-5,6,7,8-tetrahydro 2(1H)-quinazolinone in 280 ml. xylene is added 0.35 g. palladium on charcoal catalyst (10%) and the mixture refluxed for 24 hours. The catalyst is then removed by filtration and the filtrate evaporated to leave a crystalline residue which crystallizes from ethyl acetate to yield 7-methyl-1-isopropyl-4-phenyl-4,5-dihydro 2(1H)-quinazolinone.

Workup

  1. customThe catalyst is then removed by filtration
  2. customthe filtrate evaporated
  3. customto leave a crystalline residue which
  4. customcrystallizes from ethyl acetate

Sources & evidence

ORD record
ord-6f89daa8aa054ea5b037fe303057749d
Source dataset
uspto-grants-1976_12
Patent number
US03996227

Reaction notes

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