2-Butyn-1-ol, 4-chloro- → HCID 21492750, compound

HRID 1973100Notes

Reaction equation

HRID 1973100 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH:11]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:10]3[CH:19]=[C:20]([S:23][CH3:24])[CH:21]=[CH:22][C:9]=3[S:8][C:7]=2[CH:25]=1.Cl[CH2:27][C:28]#[C:29][CH2:30][OH:31]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH:11]([N:13]3[CH2:14][CH2:15][N:16]([CH2:27][C:28]#[C:29][CH2:30][OH:31])[CH2:17][CH2:18]3)[C:10]3[CH:19]=[C:20]([S:23][CH3:24])[CH:21]=[CH:22][C:9]=3[S:8][C:7]=2[CH:25]=1

Participants

3

Reactant 2

HCID 2027752-Butyn-1-ol, 4-chloro-HCID 134982451-(10,11-Dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-yl)-piperazine

Product 1

HCID 21492750HCID 21492750, compound

Procedure

In a manner analogous to that described in Example 5, from 1-[10,11-dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-yl]-piperazine and 4-chloro-2-butyn-1-ol there is obtained 4-{4-[10,11-dihydro-3-methoxy-8-methylthio-dibenzo-[b,f]thiepin-10-yl]-1-piperazinyl}-2-butyn-1-ol, the dihydrochloride of which melts at 208°-210° C.

Sources & evidence

ORD record
ord-e8adcc97324c493899439934ec7ed550
Source dataset
uspto-grants-1976_12
Patent number
US03996229

Reaction notes

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