HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Ammonium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3,4,5,6-Pentafluoroaniline hydrochloride | HCID 19351731 | — |
| Reactant | HCID 178512341 | HCID 178512341 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | (1E)-1-[amino-(2,3,4,5,6-pentafluoroanilino)methylidene]-2-cyclopropylguanidine | HCID 178512343 | — |
Reaction Steps
A mixture of 7.0 g (0.035 mole) of 2,3,4,5,6-pentafluoroaniline hydrochloride and 4.4 g (0.035 mole) of 1-cyclopropyl-3-cyanoguanidine is heated at a melt for 11/2 hours. The mixture is then cooled, heated with 25 ml of water until solution and then made alkaline with 40% sodium hydroxide. The solution is extracted with ether and dried over potassium carbonate and evaporated to dryness. The residue is chromatogramed on silica gel using isopropanol:NH4OH to obtain 1-(2,3,4,5,6-pentafluorophenyl)-5-cyclopropylbiguanide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996232 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-5a68ec6cfd4d4f229c3abf05e7ab0361 |
| Source note | uspto-grants-1976_12 |