反应详情

A mixture of 7.0 g (0.035 mole) of 2,3,4,5,6-pentafluoroaniline hydrochloride and 4.4 g (0.035 mole) of 1-cyclopropyl-3-cyanoguanidine is heated at a melt for 11/2 hours. The mixture is then cooled, heated with 25 ml of water until solution and then made alkaline with 40% sodium hydroxide. The solution is extracted with ether and dried over potassium carbonate and evaporated to dryness. The residue is chromatogramed on silica gel using isopropanol:NH4OH to obtain 1-(2,3,4,5,6-pentafluorophenyl)-5-cyclopropylbiguanide.

1. temperatureis heated at a melt for 11/2 hours
2. temperatureThe mixture is then cooled
3. extractionThe solution is extracted with ether
4. dry with materialdried over potassium carbonate
5. customevaporated to dryness