1-Ethylpiperazine → HCID 21492772, compound

HRID 1973128Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH2:23]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[CH3:24]>>[Cl:22][C:19]1[CH:20]=[CH:21][C:7]2[N:6]3[C:2]([N:28]4[CH2:29][CH2:30][N:25]([CH2:23][CH3:24])[CH2:26][CH2:27]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 21492778HCID 21492778, compound

Product 1

HCID 21492772HCID 21492772, compound

Procedure

In the manner given in Example 1, 1-bromo-8-chloro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess of 1-ethylpiperazine to give 8-chloro-1-(4-ethylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-a65247b080a6455b9a0e884010fdfd75
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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