Piperazine → HCID 21492802, compound

HRID 1973130Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:8]=3[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[N:10][CH:11]([CH2:12][CH3:13])[C:5]2=[N:4][N:3]=1.[NH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:25][C:24]([F:27])([F:26])[C:21]1[CH:22]=[CH:23][C:7]2[N:6]3[C:2]([N:28]4[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]4)=[N:3][N:4]=[C:5]3[CH:11]([CH2:12][CH3:13])[N:10]=[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[C:8]=2[CH:20]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 21492798HCID 21492798, compound

Product 1

HCID 21492802HCID 21492802, compound

Procedure

In the manner given in Example 1, 1-bromo-8-(trifluoromethyl)-4-ethyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess of piperazine to give 8-(trifluoromethyl)-4-ethyl-1-piperazino-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-5d9ec2ebeb2140e49e60c0bc4c93b91e
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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