1-Methylpiperazine → HCID 21492848, compound

HRID 1973133Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[C:19]([Br:25])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[Br:25][C:19]1[C:20]([N+:22]([O-:24])=[O:23])=[CH:21][C:7]2[N:6]3[C:2]([N:30]4[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 21492801HCID 21492801, compound

Product 1

HCID 21492848HCID 21492848, compound

Procedure

In the manner given in Example 1, 1,8-dibromo-9-nitro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with 1-methylpiperazine to give 8-bromo-9-nitro-1-(4-methylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-b62a3235f372463db7540e17497b8dea
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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