1-Ethylpiperazine → HCID 21492762, compound

HRID 1973135Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:8]=3[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[N:10][CH:11]([CH2:12][CH2:13][CH3:14])[C:5]2=[N:4][N:3]=1.[CH2:26]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[CH3:27]>>[F:25][C:22]1[CH:23]=[CH:24][C:7]2[N:6]3[C:2]([N:31]4[CH2:32][CH2:33][N:28]([CH2:26][CH3:27])[CH2:29][CH2:30]4)=[N:3][N:4]=[C:5]3[CH:11]([CH2:12][CH2:13][CH3:14])[N:10]=[C:9]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)[C:8]=2[CH:21]=1

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 21492794HCID 21492794, compound

Product 1

HCID 21492762HCID 21492762, compound

Procedure

In the manner given in Example 1, 1-bromo-8-fluoro-4-propyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with 1-ethylpiperazine to give 8-fluoro-4-propyl-1-(4-ethylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-6c4262563f60440483a0627b8641f824
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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