1-Methylpiperazine → HCID 21492788, compound

HRID 1973136Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([C:2]2[N:6]3[C:7]4[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=4[C:9]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=4)=[N:10][CH2:11][C:5]3=[N:4][N:3]=2)[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 21492763HCID 21492763, compound

Product 1

HCID 21492788HCID 21492788, compound

Procedure

In the manner given in Example 1, 1-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess 1-methylpiperazine to give 1-(4-methyl-piperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-bb986164dfb34fa8aff48b822db4fc32
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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