1-Ethylpiperazine → HCID 21492819, compound

HRID 1973137Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[C:21]([N+:22]([O-:24])=[O:23])=[CH:20][C:19]([Br:25])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH2:26]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[CH3:27]>>[Br:25][C:19]1[CH:20]=[C:21]([N+:22]([O-:24])=[O:23])[C:7]2[N:6]3[C:2]([N:31]4[CH2:32][CH2:33][N:28]([CH2:26][CH3:27])[CH2:29][CH2:30]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1

Participants

Reactant 2

HCID 791961-Ethylpiperazine

HCID 21492810HCID 21492810, compound

Product 1

HCID 21492819HCID 21492819, compound

Procedure

In the manner given in Example 1, 1,8-dibromo-10-nitro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with 1-ethylpiperazine to give 8-bromo-10-nitro-1-(4-ethylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-5cc716564b10474493dd55ce9eb68c64
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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