1-Methylpiperazine → HCID 21492807, compound

HRID 1973140Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[C:21]([CH3:22])=[CH:20][C:19]([Br:23])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[Br:23][C:19]1[CH:20]=[C:21]([CH3:22])[C:7]2[N:6]3[C:2]([N:28]4[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 21492825HCID 21492825, compound

Product 1

HCID 21492807HCID 21492807, compound

Procedure

In the manner given in Example 1, 1,8-dibromo-10-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with 1-methylpiperazine to give 8-bromo-10-methyl-1-(4-methylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-d5ecfd6e117340baafd46d00a45f0b4e
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

Loading…